International Sicca Award

- Edition 2005 -

Research Projects Russia

Yulia I. Kudryashova
Ural State Medical Academy of Postgraduate Studies, Chelyabinsk

Cryopreserved amniotic membrane transplantation in treatment of pure corneal ulcers at dry eye syndrome

Authors studied the efficiency of amniotic membrane transplantation of in treatment of pure corneal ulcers at dry eye syndrome. There were 235 patients under supervision, 145 of them had rapidly progressive course. All patients were performed different surgical interventions in combination with conservative therapy. Transplantation of amniotic membranes were lead to 38 patients. It was stacked to a cornea by epithelium and filed to episclera. At 89,5 % of patients full restoration of cornea tissue was marked in 1,5-3 months. Thus, this method in combination with conservative therapy is perspective and giving sianificant reoarative result.

Sergei Y. Slonimsky
Russian State Medical University, Moscow

Postkeratoplastic syndrome of dry eye

In the article the author describe the algorithm of conducting patients with postkeratoplastic dry eye syndrome depending on the degree of its severity. There were 66 patients after penetrating keratoplasty under supervision. In the postoperative period there were following problems: slow epithelisation of the transplant (in most cases more than 6 day), high probability of development of purulent process, increase of intraocular pressure, etc. Patients were divided into 3 groups on the degree of severity of developed dry eye syndrome, depending on terms of full transplant epithelisation. Treatment was individual for each group, keratoprotectors (Corneregel, Vi-disic) were an obligatory part of therapy. Surgical interventions were performed in 3 weeks after the beginning of treatment at absence of a positive effect. Adequate therapy before and after operation allowed to lower the probability of development epithelial problems at patients after penetrating keratoplasty.

Elena V. Yani
Helmholtz Institute
of Ophthalmology, Moscow

Prevalence of dry eye syndrome at patients transferred adenoviral Ophtalmo-infection

There were 96 patients with adenoviral eye diseases under supervision, unsatisfied with results of the lead treatment. All patients received antiviral, antiallergic and anti-inflammatory therapy, were regulary examined for revealing dry eye syndromes attributes. Development of dry eye syndrome was diagnosed on the 28th day from the beginning of disease at 41 % of women and 19 % of men. Gradually the quantity of patients with dry eye syndrome increased and constituted 94 % among women and 62 % among men in 18 months. For prophylaxis of dry eye syndrome rational therapy of adenoviral eye diseases in the sharp period, early diagnostics of dry eye syndrome and long correction of defection of tear film are necessary.

Dmitri Y. Maitchouk
Svyatoslav Fyodorov State Institute, Eye Microsurgery Complex, Moscow

Clinical forms of secondary dry eye: study of patho-genesis, development of algorithms of therapy and prophylaxis

The author systematized the basic clinical forms of secondary dry eye and defined distinctions in their patho-genesis, prophylaxis and treatment. 264 patients were examined and divided into 6 groups depending on the reason of occurrence of the syndrome. Pathogenetic mechanisms were revealed for each group as well as individual schemes of preventive maintenance and treatment were developed. For example, dry eye syndrome at patients with allergic conjunctivitis was eliminated by lance of antiedematous therapy, with secondary cornea dystrophy - by lanse of reparative, anti-inflammatory therapy and tears substitutes, etc. The frequency of development of a heavy stage of secondary dry eye decreased considerably at the duly beginning of therapy.

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